ABSTRACT
Background: Cancer is uncontrolled growth of cells with potential of local invasion and distant metastasis. The risk of developing cancer is affected by important demographic and geographic factors in addition to specific risk factors associated with individual cancers. Cancer is uncontrolled growth of cells with potential of local invasion and distant metastasis. The risk of developing cancer is affected by important demographic and geographic factors in addition to specific risk factors associated with individual cancers.Methods: This was a retrospective and an observational study comprising of 142 histopathologically diagnosed cases of cancer . Study was carried out in the department of Pathology using retrospective data of the year 2017 from January till December. Hematological malignancies were not included.Results: At the end of study highest incidence of GIT and oral cancer was observed in 35.2% samples followed by cancer breast 28.1% and uterus and adnexa in 15.4%. In 6% and 4.2% of biopsies cancer of skin and soft tissues and prostate was verified respectively. Very few cases of thyroid, renal, lymphnode and bladder cancers were observed in the present study.Conclusions: Awareness and screening programs regarding risk factors of cancer and its early diagnosis along with stringent action by the Government to restrict the use of pesticides is the need of the hour to control cancer in Punjab.
ABSTRACT
Mycosis fungoides is a cutaneous T-cell lymphoma with a high risk for developing secondary malignancies, especially B-cell lymphoproliferative disorders. About 40 cases of Hodgkin's lymphoma associated with mycosis fungoides have been reported in literature till date. We report a case of a 35-year-old gentleman who presented with intensely itchy reddish lesions all over the body. Multiple skin biopsies taken from the lesions on scalp and back confirmed the clinical diagnosis of mycosis fungoides. While on treatment, he presented with multiple bilateral cervical, axillary and inguinal lymphadenopathy 9 years after the primary diagnosis of mycosis fungoides. Excision biopsy of a cervical lymph node revealed partial effacement of architecture by a tumor comprising polymorphous background. Histopathology and immunohistochemistry revealed a diagnosis of Hodgkin's lymphoma - nodular sclerosis subtype. The patient was started on chemotherapy for stage IV Hodgkin's lymphoma. Our case emphasizes the importance of keeping secondary Hodgkin's lymphoma in mind while dealing with a patient of mycosis fungoides. Our case immunohistochemically supports the distinct etiopathogenesis of Epstein–Barr virus-negative Hodgkin's lymphoma vis-à-vis cutaneous mycosis fungoides.
ABSTRACT
Background & objectives: The epidemiology of dengue fever (DF) is complex in the Indian subcontinent as all the four serotypes are circulating. This study reports observations on dengue cases from a virus diagnostic laboratory of a north Indian tertiary care hospital catering to areas in and around Lucknow, Uttar Pradesh. Methods: Serum samples were obtained from suspected cases of dengue referred to the virus diagnostic laboratory during 2011 to 2013, and detailed history was taken on a pre-structured datasheet. All samples were tested for anti-dengue virus (DV) IgM antibodies and DV-non structural protein 1 antigen (NS1Ag) by ELISA. NS1Ag positive samples were tested further by conventional RT-PCR for DV-RNA detection and serotyping. Results: Of the 4019 suspected patients of dengue, 886 (22%) showed laboratory evidence of dengue virus infection. Of these, 19, 17 and 27 per cent were positive in 2011, 2012 and 2013, respectively. Children and adults were similarly affected by dengue in all the three years. Males were more commonly affected than females. The predominant DV serotype detected was DV-2, DV-1 and DV-3 in 2011, 2012 and 2013, respectively. DV-4 serotype was not detected. About half the cases positive for DV infection, showed symptoms of dengue with warning signs/ severe dengue. A distinct seasonality with increase in number of dengue cases in the post monsoon period was seen. Interpretation & conclusions: Change in circulating serotype of dengue virus; a distinct adult dengue involvement; and a remarkable number of cases presenting with severe dengue manifestations are the main findings of this study.